OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
References
Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.
Rat OX-40L / TNFSF4 / CD252 Gene ORF cDNA clone expression plasmid,without any tag, Related Products