Full length Clone DNA of Mouse biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) Gene ORF cDNA clone expression plasmid,without any tag
BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. BPHL also activates valacyclovir to acyclovir. It may play a role in detoxification processes.
References
Lai L. et al., 2008, J Biol Chem. 283 (14): 9318-27.
Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Hendrickson SL. et al., 2010, PLoS One. 5 (9): e12862.
Mouse BPHL Gene ORF cDNA clone expression plasmid,without any tag, Related Products