TYR is a melanosomal membrane-bound glycoprotein with a native molecular weight of 55kD, which increases to 65-75kD following post-translational modification at six potential N-glycosylation sites as it traffics to the mature melanosome. It is the key enzyme for pigmentation that catalyzes the oxidation of its substrates tyrosine and DOPA to form the intermediate DOPAquinone.
References
Jagirdar K, Smit DJ, Ainger SA, et al. Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment cell & melanoma research. 2014;27(4):552-564.
Human TYR Gene ORF cDNA clone expression plasmid,without any tag, Related Products