Full length Clone DNA of Human sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Gene ORF cDNA clone expression plasmid,without any tag
Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. SULT2A1 is a sulfo-conjugating phase II enzyme expressed at very high levels in the liver and intestine, the two major first-pass metabolic tissues, and in the steroidogenic adrenal tissue. SULT2A1 acts preferentially on the hydroxysteroids dehydroepiandrosterone, testosterone/dihydrotestosterone, and pregnenolone and on cholesterol-derived amphipathic sterol bile acids.
References
Chatterjee, B. 2005, Methods Enzymol. 400:165-91.
Liu,Y. et al., 2006, Chem Res Toxicol. 19 (11):1420-5.
Sinclair, PA. et al., 2006, J Mol Endocrinol 36 (2):301-11.
Yalcin, EB. et al., 2008, Drug Metab Lett 2 (3):198-204.
Human SULT2A1 Gene ORF cDNA clone expression plasmid,without any tag, Related Products
