STX3, also known as syntaxin 3, belongs to the syntaxin family. STX3 is a target membrane protein (t-SNARE) which is needed for membrane fusion. Membrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and t-SNAREs. STX3, together with syntaxin 2, are predominantly localized at the plasma membrane. Syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network. It is possible that this cycling has an important role in the regulation of t-SNARE function.
References
Ibaraki K. et al., 1995, Biochem Biophys Res Commun. 211 (3): 997-1005
Martín-Martín B. et al., 1999, J Leukoc Biol. 65 (3): 397-406.
Darios F. et al., 2006, Nature. 440 (7085): 813-7.
Human STX3 / Syntaxin 3 Gene ORF cDNA clone expression plasmid,without any tag, Related Products