GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in glutathione homeostasis. GGCT also induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Pseudogenes of GGCT gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
References
Wagner SA. et al., 2011, Mol Cell Proteomics. 10 (10): M111.013284.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Amano T. et al., 2012, J Histochem Cytochem. 60 (1): 76-86.
Rhesus GGCT Gene ORF cDNA clone expression plasmid,without any tag, Related Products