ECD, also known as ecdysoneless homolog, belongs to the SGT1 family. It is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. This function is related to its ability to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors. It is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. ECD may also be a transcriptional activator required for the expression of glycolytic genes.
References
Badzek S. et al., 2011, Wien Klin Wochenschr. 123 (23-24): 726-31.
Zhao X. et al., 2012, Breast Cancer Res Treat. 134 (1): 171-80.
Dey P. et al., 2012, Clin Cancer Res. 18 (22): 6188-98.
Human ECD / Ecdysoneless homolog Gene ORF cDNA clone expression plasmid,without any tag, Related Products