Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one?peptidase S1 domain. Coagulation factor IX / F9 is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ons, phospholipids, and factor VIIIa. Defects in Coagulation factor IX / F9 are the cause of thrombophilia due to factor IX defect which is a hemostatic disorder characterized by a tendency to thrombosis. Defects in Coagulation factor IX / F9 are also the cause of recessive X-linked hemophilia B ( HEMB ) which also known as Christmas disease.
References
Onay U.V., et al., 2003, Br. J. Haematol. 120:656-659.
Vidal F., et al., 2000, Br. J. Haematol. 111:549-551.
Simioni P., et al., 2009, N. Engl. J. Med. 361:1671-1675.
Espinos C., et al., 2009, Haematologica 88:235-236.
Rat Coagulation Factor IX / FIX / F9 Gene ORF cDNA clone expression plasmid,without any tag, Related Products