CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator.CIRBP can bind the 3 translated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.
References
Artero-Castro A. et al., 2009, Mol Cell Biol. 29 (7): 1855-68.
Zeng Y. et al., 2009, J Cell Biochem. 107 (1): 179-88.
Brochu C. et al., 2013, PLoS One. 8 (2): e57426.
Rhesus CIRBP / Cold-inducible RNA-binding Protein Gene ORF cDNA clone expression plasmid,without any tag, Related Products