CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function.
References
Watari A. et al., 2007, Oncogene. 25 (56): 7373-80.
De Corte V. et al., 2005, J Cell Sci. 117 (22): 5283-92.
Van Impe K. et al., 2003, J Biol Chem. 278 (20): 17945-52.
Human CAPG / AFCP Gene ORF cDNA clone expression plasmid,without any tag, Related Products
