AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for AKR1C2 gene.
References
Jin Y. et al., 2011, Biochem J. 437 (1): 53-61.
Veilleux A. et al., 2012, Am J Physiol Endocrinol Metab. 302 (8): E941-9.
Kuang P. et al., 2012, Lung Cancer. 77 (2): 427-32.
Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid,without any tag, Related Products
